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Phase 2 study of AKB-6548, a novel hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI) in patients with end stage renal disease (ESRD) undergoing hemodialysis (HD)

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The antitumor activity was expressed as the reduction of cell viability in response to cell exposure to different concentrations of the nanomaterial compared to the untreated control cells

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It participates in energy production in mitochondria, DNA repair, and activation of sirtuins, a group of proteins involved in regulating cellular aging